Vitamin C induces specific demethylation of H3K9me2 in mouse embryonic stem cells via Kdm3a/b. Authors: Ebata KT, Mesh K, Liu S, Bilenky M, Fekete A, Acker MG, Hirst M, Garcia BA, Ramalho-Santos M.Reference: Epigenetics Chromatin. 2017 Jul 12;10:36. doi: 10.1186/s13072-017-0143-3. eCollection 2017.PMID: 28706564 Read More Santos LabJuly 12, 2017Embryonic stem cells, Epigenetics, Histone lysine demethylase, Histone methylation, Vitamin C, 2017
Chd1 is essential for the high transcriptional output and rapid growth of the mouse epiblast. Authors: Guzman-Ayala M, Sachs M, Koh FM, Onodera C, Bulut-Karslioglu A, Lin CJ, Wong P, Nitta R, Song JS, Ramalho-Santos M.Reference: Development. 2015 Jan 1;142(1):118-27. doi: 10.1242/dev.114843. Epub 2014 Dec 5.PMID: 25480920 Read More Santos LabJanuary 1, 2015Chromatin, Epiblast proliferation, Epigenetics, Pluripotency, Transcription, 2015
Histone variant H3.3 maintains a decondensed chromatin state essential for mouse preimplantation development. Authors: Lin CJ, Conti M, Ramalho-Santos M.Reference: Development. 2013 Sep;140(17):3624-34. doi: 10.1242/dev.095513. Epub 2013 Jul 31.PMID: 23903189 Read More Santos LabSeptember 1, 2013Chromatin condensation, Chromosome segregation, Epigenetics, Histone acetylation, Histone methylation, Histone variant H3.3, Linker histone H1, Mouse preimplantation development, 2013
